Sample-to-result molecular diagnostic platforms and their suitability for infectious disease testing in low- and middle-income countries.
Expert Rev Mol Diagn
; 24(5): 423-438, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38747017
ABSTRACT
INTRODUCTION:
Diagnostics are an essential, undervalued part of the health-care system. For many diseases, molecular diagnostics are the gold standard, but are not easy to implement in Low- and Middle-Income Countries (LMIC). Sample-to-result (S2R) platforms combining all procedures in a closed system could offer a solution. In this paper, we investigated their suitability for implementation in LMIC. AREAS COVERED A scorecard was used to evaluate different platforms on a range of parameters. Most platforms scored fairly on the platform itself, ease-of-use and test consumables; however, shortcomings were identified in cost, distribution and test panels tailored to LMIC needs. The diagnostic coverage for common infectious diseases was found to have a wider coverage in high-income countries (HIC) than LMIC. A literature study showed that in LMIC, these platforms are mainly used as diagnostic tools or evaluation of diagnostic performance, with a minority assessing the operational characteristics or the clinical utility. In this narrative review, we identified various points for adaptation of S2R platforms to LMIC conditions. EXPERT OPINION For S2R platforms to be suitable for implementation in LMIC some modifications by the manufacturers could be considered. Furthermore, strengthening health systems and digitalization are vital; as are smaller, cheaper, faster, and sustainable technologies.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Doenças Transmissíveis
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Técnicas de Diagnóstico Molecular
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Países em Desenvolvimento
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article