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Tumor Microenvironment-Activatable Phototheranostic: Leveraging Nitric Oxide and Weak Acidity as Dual Biomarkers for Ratiometric Fluorescence, Photoacoustic Imaging, and Photothermal Therapy.
Ren, Xiaojie; Han, Shaohui; Li, Yiling; Zeng, Yuyang; Li, Haipu; Yao, Chaoyi; Yang, Lei; Song, Xiangzhi.
Afiliação
  • Ren X; College of Chemistry & Chemical Engineering, Central South University, Changsha 410083, Hunan, China.
  • Han S; Department of Chemistry and Center of Super-Diamond and Advanced Films (COSDAF), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong 999077, China.
  • Li Y; College of Chemistry & Chemical Engineering, Central South University, Changsha 410083, Hunan, China.
  • Zeng Y; College of Chemistry & Chemical Engineering, Central South University, Changsha 410083, Hunan, China.
  • Li H; College of Chemistry & Chemical Engineering, Central South University, Changsha 410083, Hunan, China.
  • Yao C; College of Chemistry & Chemical Engineering, Central South University, Changsha 410083, Hunan, China.
  • Yang L; College of Chemistry & Chemical Engineering, Central South University, Changsha 410083, Hunan, China.
  • Song X; Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Chemistry & Chemical Engineering, Linyi University, Linyi 276000, Shandong, China.
Anal Chem ; 96(21): 8689-8695, 2024 05 28.
Article em En | MEDLINE | ID: mdl-38748889
ABSTRACT
Tumor microenvironment-responsive phototheranostic agents are highly sought after for their ability to improve diagnostic accuracy and treatment specificity. Here, we introduce a novel single-molecule probe, POZ-NO, which is activated by nitric oxide (NO) and weak acidity, enabling dual-mode imaging and photothermal therapy (PTT) of tumors. In acidic environments with elevated NO levels, POZ-NO exhibits a distinctive ratiometric fluorescence signal shift from the red to near-infrared, accompanied by a 700 nm photoacoustic signal. Additionally, POZ-NO demonstrated potent photothermal effects upon NO and acidity activation, achieving an impressive conversion efficiency of 74.3% under 735 nm laser irradiation. In vivo studies confirm POZ-NO's ability to accurately image tumors through ratiometric fluorescence and photoacoustic modes while selectively treating tumors with PTT.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microambiente Tumoral / Técnicas Fotoacústicas / Terapia Fototérmica / Óxido Nítrico Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microambiente Tumoral / Técnicas Fotoacústicas / Terapia Fototérmica / Óxido Nítrico Idioma: En Ano de publicação: 2024 Tipo de documento: Article