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Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson' s disease cohorts.
Liu, Jiabin; Wang, Yige; Zhao, Yuwen; Pan, Hongxu; Liu, Zhenhua; Xu, Qian; Lu, Shen; Jiang, Hong; Wang, Junling; Sun, Qiying; Tan, Jieqiong; Yan, Xinxiang; Li, Jinchen; Tang, Beisha; Guo, Jifeng.
Afiliação
  • Liu J; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Wang Y; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Zhao Y; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Pan H; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Liu Z; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South U
  • Xu Q; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Lu S; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Jiang H; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Wang J; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Sun Q; Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Tan J; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
  • Yan X; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Li J; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China; Department of Geriatri
  • Tang B; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South U
  • Guo J; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South U
Mech Ageing Dev ; 219: 111940, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38750970
ABSTRACT
To clarify the genetic role of phospholipase A2 (PLA2) genes in Parkinson's disease (PD), we performed a genetic association study in large Chinese population cohorts using next-generation sequencing. In this study, we analyzed both rare and common variants of 38 phospholipase A2 genes in two large cohorts. We detected 1558 and 1115 rare variants in these two cohorts, respectively. In both cohorts, we observed suggestive associations between specific subgroups and the risk of PD. At the single-gene level, several genes (PLA2G2D, PLA2G12A, PLA2G12B, PLA2G4F, PNPLA1, PNPLA3, PNPLA7, PLA2G7, PLA2G15, PLAAT5, and ABHD12) are suggestively associated with PD. Meanwhile, 364 and 2261 common variants were identified in two cohorts, respectively. Our study has expanded the genetic spectrum of the PLA2 family genes and suggested potential pathogenetic roles of PLA2 superfamily in PD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Fosfolipases A2 Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Fosfolipases A2 Idioma: En Ano de publicação: 2024 Tipo de documento: Article