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Proton Beam Therapy for Intrahepatic Cholangiocarcinoma: A Multicenter Prospective Registry Study in Japan.
Mizumoto, Masashi; Terashima, Kazuki; Makishima, Hirokazu; Suzuki, Motohisa; Ogino, Takashi; Waki, Takahiro; Iwata, Hiromitsu; Tamamura, Hiroyasu; Uchinami, Yusuke; Akimoto, Tetsuo; Okimoto, Tomoaki; Iizumi, Takashi; Murakami, Masao; Katoh, Norio; Maruo, Kazushi; Shibuya, Kei; Sakurai, Hideyuki.
Afiliação
  • Mizumoto M; Department of Radiation Oncology, University of Tsukuba, Tsukuba, Japan.
  • Terashima K; Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Japan.
  • Makishima H; Department of Radiation Oncology, University of Tsukuba, Tsukuba, Japan.
  • Suzuki M; Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan.
  • Ogino T; Medipolis Proton Therapy and Research Center, Ibusuki, Japan.
  • Waki T; Department of Radiology, Tsuyama Chuo Hospital, Tsuyama, Japan.
  • Iwata H; Department of Radiation Oncology, Nagoya Proton Therapy Center, Nagoya City University West Medical Center, Nagoya, Japan.
  • Tamamura H; Proton Therapy Center, Fukui Prefectural Hospital, Fukui, Japan.
  • Uchinami Y; Department of Radiation Oncology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
  • Akimoto T; Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, Japan.
  • Okimoto T; Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Japan.
  • Iizumi T; Department of Radiation Oncology, University of Tsukuba, Tsukuba, Japan.
  • Murakami M; Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan.
  • Katoh N; Department of Radiation Oncology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
  • Maruo K; Department of Biostatistics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Shibuya K; Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Japan.
  • Sakurai H; Department of Radiation Oncology, University of Tsukuba, Tsukuba, Japan.
Liver Cancer ; 13(2): 161-168, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38751552
ABSTRACT

Introduction:

Intrahepatic cholangiocarcinoma (ICC) can be treated with chemotherapy in unresectable cases, but outcomes are poor. Proton beam therapy (PBT) may provide an alternative treatment and has good dose concentration that may improve local control.

Methods:

Fifty-nine patients who received initial PBT for ICC from May 2016 to June 2018 at nine centers were included in the study. The treatment protocol was based on the policy of the Japanese Society for Radiation Oncology. Forty patients received 72.6-76 Gy (RBE) in 20-22 fr, 13 received 74.0-76.0 Gy (RBE) in 37-38 fr, and 6 received 60-70.2 Gy (RBE) in 20-30 fr. Overall survival (OS) and progression-free survival (PFS) were estimated by Kaplan-Meier analysis.

Results:

The 59 patients (35 men, 24 women; median age 71 years; range 41-91 years) had PS of 0 (n = 47), 1 (n = 10), and 2 (n = 2). Nine patients had hepatitis and all 59 cases were considered inoperable. The Child-Pugh class was A (n = 46), B (n = 7), and unknown (n = 6); the median maximum tumor diameter was 5.0 cm (range 2.0-15.2 cm); and the clinical stage was I (n = 12), II (n = 19), III (n = 10), and IV (n = 18). At the last follow-up, 17 patients were alive (median follow-up 36.7 months; range 24.1-49.9 months) and 42 had died. The median OS was 21.7 months (95% CI 14.8-34.4 months). At the last follow-up, 37 cases had recurrence, including 10 with local recurrence. The median PFS was 7.5 months (95% CI 6.1-11.3 months). In multivariable analyses, Child-Pugh class was significantly associated with OS and PFS, and Child-Pugh class and hepatitis were significantly associated with local recurrence. Four patients (6.8%) had late adverse events of grade 3 or higher.

Conclusion:

PBT gives favorable treatment outcomes for unresectable ICC without distant metastasis and may be particularly effective in cases with large tumors.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article