Optogenetic activation of dorsal raphe serotonin neurons induces brain-wide activation.
Nat Commun
; 15(1): 4152, 2024 May 16.
Article
em En
| MEDLINE
| ID: mdl-38755120
ABSTRACT
Serotonin is a neuromodulator that affects multiple behavioral and cognitive functions. Nonetheless, how serotonin causes such a variety of effects via brain-wide projections and various receptors remains unclear. Here we measured brain-wide responses to optogenetic stimulation of serotonin neurons in the dorsal raphe nucleus (DRN) of the male mouse brain using functional MRI with an 11.7 T scanner and a cryoprobe. Transient activation of DRN serotonin neurons caused brain-wide activation, including the medial prefrontal cortex, the striatum, and the ventral tegmental area. The same stimulation under anesthesia with isoflurane decreased brain-wide activation, including the hippocampal complex. These brain-wide response patterns can be explained by DRN serotonergic projection topography and serotonin receptor expression profiles, with enhanced weights on 5-HT1 receptors. Together, these results provide insight into the DR serotonergic system, which is consistent with recent discoveries of its functions in adaptive behaviors.
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Base de dados:
MEDLINE
Assunto principal:
Serotonina
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Neurônios Serotoninérgicos
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Optogenética
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Núcleo Dorsal da Rafe
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article