In Vivo Modeling of Cryptococcus neoformans Infection and Collection of Murine Samples.
Methods Mol Biol
; 2775: 47-55, 2024.
Article
em En
| MEDLINE
| ID: mdl-38758310
ABSTRACT
In vivo models provide advantages to study the progression of disease and to identify potential biomarkers to detect and monitor infections. For the human fungal pathogen Cryptococcus neoformans, murine intranasal models aim to recapitulate natural infection from inhalation of desiccated fungal cells from the environment and permit monitoring of disease over time. In this chapter, we describe the establishment of a murine model for cryptococcosis and the subsequent collection of organs, tissues, and fluids for sampling. These samples may support novel diagnostic strategies and opportunities to monitor dissemination of the fungal cells throughout the host and propose new treatment options to combat disease.
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Base de dados:
MEDLINE
Assunto principal:
Criptococose
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Cryptococcus neoformans
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Modelos Animais de Doenças
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article