A Dual Ni/Photoredox Cross-Coupling Approach toward Mandelic Acids.
Org Lett
; 26(21): 4566-4570, 2024 May 31.
Article
em En
| MEDLINE
| ID: mdl-38758597
ABSTRACT
Mandelic acid derivatives represent a valuable class of compounds due to their wide use in synthetic organic chemistry and the pharmaceutical sector. Herein, we report a novel reductive Ni/photoredox cross-coupling of readily accessible, bench stable N-alkoxyphthalimides and aryl halides to prepare unprotected mandelic acid ester derivatives. Mechanistic experiments suggest that this cross-coupling likely proceeds via a pathway that is distinct from previous reports using similar redox-active alkoxy radical precursors.
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MEDLINE
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En
Ano de publicação:
2024
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Article