On the path to [Fe-S] protein maturation: A personal perspective.
Biochim Biophys Acta Mol Cell Res
; 1871(6): 119750, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38762171
ABSTRACT
Azotobacter vinelandii is a genetically tractable Gram-negative proteobacterium able to fix nitrogen (N2) under aerobic growth conditions. This narrative describes how biochemical-genetic approaches using A. vinelandii to study nitrogen fixation led to the formulation of the "scaffold hypothesis" for the assembly of both simple and complex [Fe-S] clusters associated with biological nitrogen fixation. These studies also led to the discovery of a parallel, but genetically distinct, pathway for maturation of [Fe-S] proteins that support central metabolic processes.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
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Azotobacter vinelandii
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Proteínas Ferro-Enxofre
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Fixação de Nitrogênio
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article