Advances in the regulation of inflammasome activation by GBP family in infectious diseases.
Yi Chuan
; 45(11): 1007-1017, 2023 Nov 20.
Article
em En
| MEDLINE
| ID: mdl-38764266
ABSTRACT
Guanylate-binding proteins (GBPs) are a subfamily of interferon-inducible proteins that undertake distinct roles in the the context of bacteria, virus, chlamydia and parasites infections. These proteins exert a notable influence on the progression and outcomes of infectious diseases. Within the realm of host cell-autonomous immunity against pathogens, GBPs have been identified as the regulators of pyroptosis through canonical and noncanonical inflammasome activation pathways. In this review, we summarize the structure and evolution of GBP family members, the canonical and noncanonical inflammasome activation pathways, the roles of GBPs in regulating inflammasome activation, and the mechanisms of GBPs affecting infections induced by different pathogens. We hope to provide new basic research clues for the pathogenesis and diagnosis and treatment of infectious diseases.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Ligação ao GTP
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Inflamassomos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article