Investigation of the active ingredients and mechanism of Shuangling extract in dextran sulfate sodium salt induced ulcerative colitis mice based on network pharmacology and experimental verification.
J Tradit Chin Med
; 44(3): 478-488, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38767631
ABSTRACT
OBJECTIVE:
To explore the pharmacodynamic effects and potential mechanisms of Shuangling extract against ulcerative colitis (UC).METHODS:
The bioinformatics method was used to predict the active ingredients and action targets of Shuangling extract against UC in mice. And the biological experiments such as serum biochemical indexes and histopathological staining were used to verify the pharmacological effect and mechanism of Shuangling extract against UC in mice.RESULTS:
The Shuangling extract reduced the levels of seruminterleukin-1ß (IL-1ß), tumor necrosis factor-α (TNF-N), interleukin-6 (IL-6) and other inflammatory factors in UC mice and inhibited the inflammatory response. AKT Serine/threonine Kinase 1 and IL-6 may be the main targets of the anti-UC action of Shuangling extract, and the TNF signaling pathway, Forkhead box O signaling pathway and T-cell receptor signaling pathway may be the main signaling pathways.CONCLUSION:
The Shuangling extract could inhibit the inflammatory response induced by UC and regulate intestinal immune function through multiple targets and multiple channels, which provided a new option and theoretical basis for anti-UC.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Colite Ulcerativa
/
Sulfato de Dextrana
/
Fator de Necrose Tumoral alfa
/
Farmacologia em Rede
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article