Mechanisms of antibody mediated immunity - Distinct in early life.
Int J Biochem Cell Biol
; 172: 106588, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38768890
ABSTRACT
Immune responses in early life are characterized by a failure to robustly generate long-lasting protective responses against many common pathogens or upon vaccination. This is associated with a reduced ability to generate T-cell dependent high affinity antibodies. This review highlights the differences in T-cell dependent antibody responses observed between infants and adults, in particular focussing on the alterations in immune cell function that lead to reduced T follicular helper cell-B cell crosstalk within germinal centres in early life. Understanding the distinct functional characteristics of early life humoral immunity, and how these are regulated, will be critical in guiding age-appropriate immunological interventions in the very young.
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Base de dados:
MEDLINE
Assunto principal:
Imunidade Humoral
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article