What Proportion of BRCA-Associated Breast Cancer Is Human Epidermal Growth Factor 2-Low and Eligible for Additional Targeted Therapy?

Forester, Emily; Belsare, Aakash; Kim, Dong Won; Whitaker, Kristen; Obeid, Elias; Goldstein, Lori J; Bleicher, Richard J; Daly, Mary B; Williams, Austin D

Forester, Emily; Belsare, Aakash; Kim, Dong Won; Whitaker, Kristen; Obeid, Elias; Goldstein, Lori J; Bleicher, Richard J; Daly, Mary B; Williams, Austin D.

Afiliação

Forester E; Division of Breast Surgical Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania; Rowan-Virtua School of Osteopathic Medicine, Stratford, New Jersey.
Belsare A; Division of Breast Surgical Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania; Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania.
Kim DW; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Whitaker K; Department of Medical Oncology, MedStar Health, Washington, District of Columbia.
Obeid E; Hackensack Meridian Health Network, Edison, New Jersey.
Goldstein LJ; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Bleicher RJ; Division of Breast Surgical Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Daly MB; Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Williams AD; Division of Breast Surgical Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania; Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania. Electronic address: austin.williams@fccc.edu.

J Surg Res ; 299: 217-223, 2024 Jul.

Article em En | MEDLINE | ID: mdl-38776577

Assuntos

Proteína BRCA1; Proteína BRCA2; Terapia de Alvo Molecular; Receptor ErbB-2; Humanos; Feminino; Estudos Retrospectivos; Receptor ErbB-2/genética; Receptor ErbB-2/metabolismo; Receptor ErbB-2/análise; Pessoa de Meia-Idade; Adulto; Proteína BRCA1/genética; Proteína BRCA2/genética; Idoso; Terapia de Alvo Molecular/métodos; Neoplasias de Mama Triplo Negativas/genética; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Mutação em Linhagem Germinativa; Neoplasias da Mama/genética; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/patologia

Palavras-chave

Breast cancer; Breast cancer type 1 gene pathogenic variants; HER2-Low; Human epidermal growth factor 2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor ErbB-2 / Proteína BRCA1 / Proteína BRCA2 / Terapia de Alvo Molecular Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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