Diruthenium Paddlewheel Complexes Attacking Proteins: Axial versus Equatorial Coordination.
Biomolecules
; 14(5)2024 Apr 28.
Article
em En
| MEDLINE
| ID: mdl-38785937
ABSTRACT
Metallodrugs are an important group of medicinal agents used for the treatment of various diseases ranging from cancers to viral, bacterial, and parasitic diseases. Their distinctive features include the availability of a metal centre, redox activity, as well as the ability to multitarget. Diruthenium paddlewheel complexes are an intensely developing group of metal scaffolds, which can securely coordinate bidentate xenobiotics and transport them to target tissues, releasing them by means of substitution reactions with biomolecular nucleophiles. It is of the utmost importance to gain a complete comprehension of which chemical reactions happen with them in physiological milieu to design novel drugs based on these bimetallic scaffolds. This review presents the data obtained in experiments and calculations, which clarify the chemistry these complexes undergo once administered in the proteic environment. This study demonstrates how diruthenium paddlewheel complexes may indeed embody a new paradigm in the design of metal-based drugs of dual-action by presenting and discussing the protein metalation by these complexes.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Rutênio
/
Proteínas
/
Complexos de Coordenação
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article