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Healing of Periodontal Suprabony Defects following Treatment with Open Flap Debridement with or without Hyaluronic Acid (HA) Application.
Vela, Octavia Carolina; Boariu, Marius; Rusu, Darian; Iorio-Siciliano, Vincenzo; Ramaglia, Luca; Boia, Simina; Radulescu, Viorelia; Ilyes, Ioana; Stratul, Stefan-Ioan.
Afiliação
  • Vela OC; Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
  • Boariu M; Department of Endodontics, Faculty of Dental Medicine, TADERP Research Center, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
  • Rusu D; Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
  • Iorio-Siciliano V; Department of Periodontology, School of Dental Medicine, University of Naples Federico II, 80138 Naples, Italy.
  • Ramaglia L; Department of Periodontology, School of Dental Medicine, University of Naples Federico II, 80138 Naples, Italy.
  • Boia S; Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
  • Radulescu V; Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
  • Ilyes I; Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
  • Stratul SI; Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Medicina (Kaunas) ; 60(5)2024 May 17.
Article em En | MEDLINE | ID: mdl-38793012
ABSTRACT
Background and

Objectives:

This randomized, double-arm, multicentric clinical trial aims to compare the clinical outcomes following the treatment of suprabony periodontal defects using open flap debridement (OFD) with or without the application of hyaluronic acid (HA). Materials and

Methods:

Sixty systemically healthy patients with at least two teeth presenting suprabony periodontal defects were randomly assigned with a 11 allocation ratio using computer-generated tables into a test (OFD + HA) or control group (OFD). The main outcome variable was clinical attachment level (CAL). The secondary outcome variables were changes in mean probing pocket depth (PPD), gingival recession (GR), full-mouth plaque score (FMPS), and full-mouth bleeding score (FMBS). All clinical measurements were carried out at baseline and 12 months.

Results:

Sixty patients, thirty in each group, were available for statistical analysis. The mean CAL gain was statistically significantly different (p < 0.001) in the test group compared with the control group (3.06 ± 1.13 mm vs. 1.44 ± 1.07 mm). PPD reduction of test group measurements (3.28 ± 1.14 mm) versus the control group measurements (2.61 ± 1.22 mm) were statistically significant (p = 0.032). GR changes were statistically significant only in the test group 0.74 ± 1.03 mm (p < 0.001). FMBS and FMPS revealed a statistically significant improvement mostly in the test group.

Conclusions:

Suprabony periodontal defects could benefit from the additional application of HA in conjunction with OFD in terms of improvement of the clinical parameters compared with OFD alone.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retalhos Cirúrgicos / Desbridamento / Ácido Hialurônico Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retalhos Cirúrgicos / Desbridamento / Ácido Hialurônico Idioma: En Ano de publicação: 2024 Tipo de documento: Article