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A very-low-calorie diet (VLCD) intervention for the management of prediabetes and early Type 2 diabetes mellitus in a multi-ethnic cohort in Aotearoa New Zealand: The PROGRESS NZ feasibility study.
Whitfield, Patricia Louise; Hall, Rosemary Megan; Théaude, Lorène; Sixtus, Ryan Phillip; Kanaan, Rami; Holley, Ana Simone; Umpleby, A Margot; Weatherall, Mark; Rowlands, David Stephen; Krebs, Jeremy David.
Afiliação
  • Whitfield PL; Department of Medicine, University of Otago, Wellington, New Zealand. Email: patricia.whitfield@postgrad.otago.ac.nz; patricia.whitfield@ccdhb.org.nz.
  • Hall RM; Endocrine, Diabetes and Research Centre, Wellington Hospital, New Zealand.
  • Théaude L; Department of Medicine, University of Otago, Wellington, New Zealand.
  • Sixtus RP; Endocrine, Diabetes and Research Centre, Wellington Hospital, New Zealand.
  • Kanaan R; Department of Medicine, University of Otago, Wellington, New Zealand.
  • Holley AS; Department of Medicine, University of Otago, Wellington, New Zealand.
  • Umpleby AM; Department of Medicine, University of Otago, Wellington, New Zealand.
  • Weatherall M; Department of Medicine, University of Otago, Wellington, New Zealand.
  • Rowlands DS; School of Biosciences, University of Surrey, UK.
  • Krebs JD; Department of Medicine, University of Otago, Wellington, New Zealand.
Asia Pac J Clin Nutr ; 33(2): 200-212, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38794980
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Very-low calorie diets (VLCD) achieve weight loss and remission of Type 2 diabetes (T2DM), but efficacy and acceptability in non-European populations is less clear. This feasibility study examines the impact of 10% weight loss through VLCD on metabolic and body composition outcomes in a multi-ethnic cohort of Aotearoa New Zealand (AoNZ) men with prediabetes/early T2DM, and VLCD tolerability/cultural acceptability. METHODS AND STUDY

DESIGN:

Participants followed a VLCD intervention (mean energy 3033kJ/day) until achievement of 10% weight loss. An oral glucose tolerance test (OGTT), hyperinsulinaemic isoglycaemic clamp with stable isotopes, hood calorimetry and dual-energy Xray absorptiometry (DXA) were undertaken before and after intervention. Qualitative data on VLCD tolerability/cultural acceptability were collected.

RESULTS:

Fifteen participants were enrolled; nine achieved 10% weight loss. In this group, mean HbA1c reduced by 4.8mmol/mol (2.4-7.1) and reverted to normoglycaemia in n=5/9; mean body weight reduced by 12.0 kg (11.0-13.1) and whole-body glucose disposal improved by 1.5 mg kgFFM-1 min-1 (0.7-2.2). Blood pressure and fasting triglycerides improved significantly. No changes in hepatic glu-cose metabolism were found. In all participants who attended completion testing, HbA1c reduced by 3.4mmol/mol (SD 3.5) and total weight by 9.0kg (SD 5.7). The intervention was highly tolerable/culturally acceptable however challenges with fulfilment of cultural obligations were described.

CONCLUSIONS:

Results support VLCD use in AoNZ however further work to investigate ethnic differences in physiological response to VLCDs and to optimise protocols for multi-ethnic populations are required.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estado Pré-Diabético / Estudos de Viabilidade / Restrição Calórica / Diabetes Mellitus Tipo 2 Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estado Pré-Diabético / Estudos de Viabilidade / Restrição Calórica / Diabetes Mellitus Tipo 2 Idioma: En Ano de publicação: 2024 Tipo de documento: Article