Efficacy and Safety of Interleukin-1 Inhibitors in the Management of Patients with Recurrent Pericarditis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Am J Cardiovasc Drugs
; 24(4): 537-545, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38809412
ABSTRACT
BACKGROUND:
The efficacy and safety of interleukin-1 (IL-1) inhibitors in patients with recurrent pericarditis (RP) remain to be determined.OBJECTIVE:
We aimed to conduct a meta-analysis to investigate the impact of IL-1 inhibitors on patients suffering from RP.METHODS:
The Cochrane Library, PubMed, EMBASE, ClinicalTrials.gov, and Web of Science databases were systematically searched to identify articles investigating the effects of IL-1 inhibitors in patients with RP up until January 2024. Relevant data on study characteristics and results were selected based on predefined criteria. The results were combined using a random effects model.RESULTS:
The study included a total of 102 patients from three open-label randomized controlled trials. Overall, the use of IL-1 inhibitors, in comparison to placebo, demonstrated a significant reduction in the risk of pericarditis recurrence [risk ratio (RR) 0.13; 95% confident interval (CI) 0.05-0.30; p < 0.05; I2 = 0%]. However, the administration of IL-1 inhibitors may lead to certain adverse events (AEs), including infections and injection-site reactions. The risk of AEs is significantly higher with IL-1 inhibitors compared with placebo (RR 1.88; 95% CI 1.30-2.72; p < 0.05; I2 = 0%). Nevertheless, the occurrence of serious AEs among patients was relatively rare, and no fatalities were reported.CONCLUSION:
This meta-analysis showed that IL-1 inhibitors can effectively reduce the risk of recurrence in patients with RP and are relatively safe. REGISTRATION PROSPERO identifier number CRD42023492904.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pericardite
/
Recidiva
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Ensaios Clínicos Controlados Aleatórios como Assunto
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Interleucina-1
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article