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Zolpidem improves task-specific dystonia: A randomized clinical trial integrating exploratory transcranial magnetic stimulation and [18F] FDG-PET imaging.
Vogelnik Zakelj, Katarina; Trost, Maja; Tomse, Petra; Petrovic, Igor N; Tomic Pesic, Aleksandra; Radovanovic, Sasa; Kojovic, Maja.
Afiliação
  • Vogelnik Zakelj K; Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia; Institute of Clinical Neurophysiology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
  • Trost M; Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia; Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia; Medical Faculty, University of Ljubljana, Slovenia.
  • Tomse P; Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia.
  • Petrovic IN; Neurology Clinic, Clinical Center of Serbia, University of Belgrade, Belgrade, Serbia.
  • Tomic Pesic A; Neurology Clinic, Clinical Center of Serbia, University of Belgrade, Belgrade, Serbia.
  • Radovanovic S; Neurology Clinic, Clinical Center of Serbia, University of Belgrade, Belgrade, Serbia.
  • Kojovic M; Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia; Medical Faculty, University of Ljubljana, Slovenia. Electronic address: maja.kojovic@kclj.si.
Parkinsonism Relat Disord ; 124: 107014, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38823169
ABSTRACT

BACKGROUND:

Task-specific dystonia (TSFD) is a disabling movement disorder. Effective treatment options are currently limited. Zolpidem was reported to improve primary focal and generalized dystonia in a proportion of patients. The mechanisms underlying its therapeutic effects have not yet been investigated.

METHODS:

We conducted a randomized, double-blind, placebo-controlled, crossover trial of single-dose zolpidem in 24 patients with TSFD. Patients were clinically assessed using Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), Writers' Cramp Rating Scale (WCRS), and Visual Analogue Scale (VAS), before and after receiving placebo and zolpidem. Transcranial magnetic stimulation was conducted on placebo and zolpidem to compare corticospinal excitability - active and resting motor thresholds (AMT and RMT), resting and active input/output curves and intracortical excitability - cortical silent period (CSP), short-interval intracortical inhibition curve (SICI), long-interval intracortical inhibition (LICI) and intracortical facilitation (ICF). Eight patients underwent brain FDG-PET imaging on zolpidem and placebo.

RESULTS:

Zolpidem treatment improved TSFD. Zolpidem compared to placebo flattened rest and active input/output curves, reduced ICF and was associated with hypometabolism in the right cerebellum and hypermetabolism in the left inferior parietal lobule and left cingulum. Correlations were found between changes in dystonia severity on WCRS and changes in active input/output curve and in brain metabolism, respectively. Patients with lower RMT, and higher rest and active input/output curves exhibited better response to zolpidem compared to placebo.

CONCLUSIONS:

Zolpidem improved TSFD by reducing corticomotor output and influencing crucial nodes in higher-order sensory and motor networks.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estudos Cross-Over / Fluordesoxiglucose F18 / Distúrbios Distônicos / Tomografia por Emissão de Pósitrons / Estimulação Magnética Transcraniana / Zolpidem Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estudos Cross-Over / Fluordesoxiglucose F18 / Distúrbios Distônicos / Tomografia por Emissão de Pósitrons / Estimulação Magnética Transcraniana / Zolpidem Idioma: En Ano de publicação: 2024 Tipo de documento: Article