Visible light-induced reductive aza-6π electrocyclization access to phenanthridines.
Org Biomol Chem
; 22(24): 4968-4972, 2024 Jun 19.
Article
em En
| MEDLINE
| ID: mdl-38825973
ABSTRACT
Visible light-induced aza-6π electrocyclization was developed for the synthesis of aza-arenes from nitroarenes with diverse aldehydes. This protocol allows the reduction of nitroarenes by B2nep2 and subsequent 6π-electrocyclization of the in situ formed imine under visible light. An array of 6- and multi-substituted phenanthridines were constructed in moderate to good yields under purple LEDs at room temperature. A wide scope of substrates with diverse functional groups were well tolerated. In addition, the synthetic utility of this methodology was further demonstrated in the late-stage functionalization of celecoxib.
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MEDLINE
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Ano de publicação:
2024
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Article