Cytokines and lymphocyte subsets are associated with disease severity of severe fever with thrombocytopenia syndrome.
Virol J
; 21(1): 126, 2024 Jun 03.
Article
em En
| MEDLINE
| ID: mdl-38831352
ABSTRACT
BACKGROUND:
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV). Previous studies have indicated that SFTS patients have a high mortality rate, which may be related to cytokine storm and immune dysfunction. In our study, we analyzed differences in cytokines and lymphocyte subsets between severe and non-severe SFTS patients, with the aim of identifying predictors of severity.METHODS:
We retrospectively analyzed demographic characteristics, clinical data, cytokine profiles, and lymphocyte subsets from 96 laboratory confirmed SFTS patients between April 2021 and August 2023.RESULTS:
A total of 96 SFTS patients were enrolled, with a mean age of 65.05 (± 7.92) years old. According to our grouping criteria, 35 (36.5%) of these patients were classified as severe group, while 61 (63.5%) were classified as non-severe group. Univariate analysis revealed that age, interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), interferon-α (IFN-α), CD4 + T cell, and CD8 + T cell counts were risk predictors for the severity of SFTS. Further multivariable logistic regression analysis confirmed age, IL-6 levels, and CD4 + T cell counts as independent predictors of SFTS severity.CONCLUSIONS:
Severe SFTS patients may experience cytokine storms and immune dysfunction. Aging, elevated levels of IL-6, and decreased CD4 + T cell count may serve as independent predictors for the severity of SFTS.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Índice de Gravidade de Doença
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Citocinas
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Subpopulações de Linfócitos
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Phlebovirus
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Febre Grave com Síndrome de Trombocitopenia
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article