Composite Microgels Loaded with Doxorubicin-Conjugated Amine-Functionalized Zinc Ferrite Nanoparticles for Stimuli-Responsive Sustained Drug Release.
Int J Nanomedicine
; 19: 5059-5070, 2024.
Article
em En
| MEDLINE
| ID: mdl-38836007
ABSTRACT
Purpose:
The purpose of this study is to address the need for efficient drug delivery with high drug encapsulation efficiency and sustained drug release. We aim to create nanoparticle-loaded microgels for potential applications in treatment development.Methods:
We adopted the process of ionic gelation to generate microgels from sodium alginate and carboxymethyl cellulose. These microgels were loaded with doxorubicin-conjugated amine-functionalized zinc ferrite nanoparticles (AZnFe-NPs). The systems were characterized using various techniques. Toxicity was evaluated in MCF-7 cells. In vitro release studies were conducted at different pH levels at 37 oC, with the drug release kinetics being analyzed using various models.Results:
The drug encapsulation efficiency of the created carriers was as high as 70%. The nanoparticle-loaded microgels exhibited pH-responsive behavior and sustained drug release. Drug release from them was mediated via a non-Fickian type of diffusion.Conclusion:
Given their high drug encapsulation efficiency, sustained drug release and pH-responsiveness, our nanoparticle-loaded microgels show promise as smart carriers for future treatment applications. Further development and research can significantly benefit the field of drug delivery and treatment development.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
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Compostos Férricos
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Doxorrubicina
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Preparações de Ação Retardada
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Liberação Controlada de Fármacos
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Microgéis
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article