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Nirsevimab Effectiveness Against Cases of Respiratory Syncytial Virus Bronchiolitis Hospitalised in Paediatric Intensive Care Units in France, September 2023-January 2024.
Paireau, Juliette; Durand, Cécile; Raimbault, Sylvain; Cazaubon, Joséphine; Mortamet, Guillaume; Viriot, Delphine; Milesi, Christophe; Daudens-Vaysse, Elise; Ploin, Dominique; Tessier, Sabrina; Vanel, Noémie; Chappert, Jean-Loup; Levieux, Karine; Ollivier, Ronan; Daoudi, Jamel; Coignard, Bruno; Leteurtre, Stéphane; Parent-du-Châtelet, Isabelle; Vaux, Sophie.
Afiliação
  • Paireau J; Direction des maladies infectieuses, Santé publique France, Saint-Maurice, France.
  • Durand C; Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Université Paris Cité, CNRS UMR 2000, Paris, France.
  • Raimbault S; Cellule Régionale Occitanie, Santé publique France, Toulouse, France.
  • Cazaubon J; Service de Réanimation et Urgences Pédiatriques, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France.
  • Mortamet G; Direction des maladies infectieuses, Santé publique France, Saint-Maurice, France.
  • Viriot D; Service de soins critiques pédiatriques, CHU Grenoble-Alpes, Grenoble, France.
  • Milesi C; Direction des maladies infectieuses, Santé publique France, Saint-Maurice, France.
  • Daudens-Vaysse E; Service de Réanimation pédiatrique, Hôpital Arnaud de Villeneuve, Montpellier, France.
  • Ploin D; Cellule Régionale Hauts-de-France, Santé publique France, Lille, France.
  • Tessier S; Service de Réanimation et Urgences Pédiatriques, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France.
  • Vanel N; Cellule Régionale Bourgogne-Franche-Comté, Santé publique France, Lille, France.
  • Chappert JL; Service de Réanimation pédiatrique, CHU de La Timone, Marseille, France.
  • Levieux K; Cellule Régionale Occitanie, Santé publique France, Montpellier, France.
  • Ollivier R; Services d'urgences pédiatriques, Centre Hospitalier Universitaire de Nantes, Nantes, France.
  • Daoudi J; Cellule Régionale Pays de la Loire, Santé publique France, Nantes, France.
  • Coignard B; Cellule Océan Indien, Santé publique France, Saint-Denis, France.
  • Leteurtre S; Direction des maladies infectieuses, Santé publique France, Saint-Maurice, France.
  • Parent-du-Châtelet I; Réanimation et Soins Intensifs Pédiatriques Polyvalents, CHU Lille, Université de Lille, ULR 2694 - METRICS: Évaluation des technologies de santé et des pratiques médicales, Lille, France.
  • Vaux S; Direction des maladies infectieuses, Santé publique France, Saint-Maurice, France.
Influenza Other Respir Viruses ; 18(6): e13311, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38840301
ABSTRACT
In September 2023, France was one of the first countries that started a national immunisation campaign with nirsevimab, a new monoclonal antibody against respiratory syncytial virus (RSV). Using data from a network of paediatric intensive care units (PICUs), we aimed to estimate nirsevimab effectiveness against severe cases of RSV bronchiolitis in France. We conducted a case-control study based on the test-negative design and included 288 infants reported by 20 PICUs. We estimated nirsevimab effectiveness at 75.9% (48.5-88.7) in the main analysis and 80.6% (61.6-90.3) and 80.4% (61.7-89.9) in two sensitivity analyses. These real-world estimates confirmed the efficacy observed in clinical studies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Unidades de Terapia Intensiva Pediátrica / Infecções por Vírus Respiratório Sincicial / Hospitalização Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Unidades de Terapia Intensiva Pediátrica / Infecções por Vírus Respiratório Sincicial / Hospitalização Idioma: En Ano de publicação: 2024 Tipo de documento: Article