Relationship between 25-hydroxy Vitamin D level and surgical site infection in spine surgery.

Liu, Serena; Sulovari, Aron; Joo, Peter; Thirukumaran, Caroline; Benn, Lancelot; Mesfin, Addisu

Liu, Serena; Sulovari, Aron; Joo, Peter; Thirukumaran, Caroline; Benn, Lancelot; Mesfin, Addisu.

Afiliação

Liu S; Department of Orthopaedic Surgery, University of Rochester Medical Center, Rochester, New York, United States.
Sulovari A; Department of Anesthesiology, Westchester Medical Center, Valhalla, New York, United States.
Joo P; Department of Orthopaedic Surgery, University of Rochester Medical Center, Rochester, New York, United States.
Thirukumaran C; Department of Orthopaedic Surgery, University of Rochester Medical Center, Rochester, New York, United States.
Benn L; Department of Orthopaedic Surgery, Howard University College of Medicine, Washington, United States.
Mesfin A; Department of Orthopaedics, MedStar Orthopaedic Institute, Washington, United States.

Surg Neurol Int ; 15: 173, 2024.

Article em En | MEDLINE | ID: mdl-38840603

ABSTRACT

ABSTRACT

Background:

25-hydroxy Vitamin D (25[OH]D) level has been shown to have antimicrobial and wound healing effects in animal models. Low preoperative 25(OH)D has been shown to correlate with surgical site infection (SSI) in thoracolumbar spine surgery.

Methods:

This study involved 545 patients undergoing thoracolumbar spine surgery from 2012 to 2019 at an academic medical center. We evaluated the serum 25(OH)D level (i.e., adequate level = level 30-60 ng/dL), along with SSI, body mass index, and smoking status. Statistical analysis was done using bivariate analysis with Fisher's exact, Wilcoxon rank-sum test and multivarible logisitic regression analyses.

Results:

We included 545 patients in the study, and there were no statistical differences in the average preoperative 25(OH)D between SSI and non-SSI groups. The average 25(OH)D in the non-SSI group was 31.6 ng/dL ± 13.6, and the SSI group was 35.7 ng/dL ± 20.2 (P = 0.63).