Self-reported gastrointestinal adverse effects of non-steroidal anti-inflammatory drugs in female students with dysmenorrhoea at Makerere University: prevalence, discontinuation and associated factors. a cross sectional study.
BMJ Open
; 14(6): e079660, 2024 Jun 06.
Article
em En
| MEDLINE
| ID: mdl-38844394
ABSTRACT
BACKGROUND:
Primary dysmenorrhoea occurs in up to 50% of menstruating females. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used therapeutic remedies for dysmenorrhoea in Uganda. However, NSAIDs are associated with a 3-5 fold increase in the risk of gastrointestinal (GI) adverse drug effects.OBJECTIVES:
We aimed to determine the prevalence and associated factors of self-reported NSAID-related GI adverse effects in female students who use NSAIDs in managing dysmenorrhoea-associated pain at Makerere University.DESIGN:
A cross-sectional study.SETTING:
Makerere University's main campus, situated North of Kampala, Uganda.PARTICIPANTS:
314 female students pursuing an undergraduate programme at Makerere University and residing in different halls of residence and hostels.OUTCOMES:
Social demographic data, menstrual history and treatment data.RESULTS:
Overall, 314 valid responses were received from female students with a median age of 22 years (IQR 18-29 years). The median age at menarche was 13 years (IQR 9-18 years). 41% (n=129/314) of the respondents had used medication for dysmenorrhoea and 32% (n=41/129) of whom reported NSAID-associated GI adverse effects with nausea being the most frequently reported (44%, n=18/41)Factors independently associated with GI adverse effects were age at menarche (p=0.026), duration of menstruation (p=0.030) and use of ibuprofen (p=0.005). Females taking ibuprofen for dysmenorrhoea were about four times as likely to have NSAID-associated GI adverse effects (adjusted OR 3.87, 95% CI 1.51 to 9.91) than those who did not receive ibuprofen. Logistic regression was used to determine factors associated with self-reported adverse effects of NSAIDs among the female students. A p<0.05 was considered statistically significant.CONCLUSION:
We found a considerably high prevalence of NSAID-related GI adverse effects driven by factors such as age at menarche and ibuprofen use.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Estudantes
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Anti-Inflamatórios não Esteroides
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Dismenorreia
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Autorrelato
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article