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Mosaic vaccine-induced antibody-dependent cellular phagocytosis associated with delayed HIV-1 viral load rebound post treatment interruption.
Mdluli, Thembi; Slike, Bonnie M; Curtis, Daniel J; Shubin, Zhanna; Tran, Ursula; Li, Yifan; Dussupt, Vincent; Mendez-Rivera, Letzibeth; Pinyakorn, Suteeraporn; Stieh, Daniel J; Tomaka, Frank L; Schuitemaker, Hanneke; Pau, Maria G; Colby, Donn J; Kroon, Eugène; Sacdalan, Carlo; de Souza, Mark; Phanupak, Nittaya; Hsu, Denise C; Ananworanich, Jintanat; Ake, Julie A; Trautmann, Lydie; Vasan, Sandhya; Robb, Merlin L; Krebs, Shelly J; Paquin-Proulx, Dominic; Rolland, Morgane.
Afiliação
  • Mdluli T; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Slike BM; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Curtis DJ; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Shubin Z; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Tran U; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Li Y; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Dussupt V; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Mendez-Rivera L; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Pinyakorn S; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Stieh DJ; Janssen Vaccines & Prevention BV, 2333 Leiden CN, the Netherlands.
  • Tomaka FL; Janssen R & D US, Titusville, NJ, USA.
  • Schuitemaker H; Janssen Vaccines & Prevention BV, 2333 Leiden CN, the Netherlands.
  • Pau MG; Janssen Vaccines & Prevention BV, 2333 Leiden CN, the Netherlands.
  • Colby DJ; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA; SEARCH, Institute of HIV Research and Innovation, Bangkok 10330, Thailand.
  • Kroon E; SEARCH, Institute of HIV Research and Innovation, Bangkok 10330, Thailand.
  • Sacdalan C; SEARCH, Institute of HIV Research and Innovation, Bangkok 10330, Thailand.
  • de Souza M; SEARCH, Institute of HIV Research and Innovation, Bangkok 10330, Thailand.
  • Phanupak N; SEARCH, Institute of HIV Research and Innovation, Bangkok 10330, Thailand.
  • Hsu DC; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Ananworanich J; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Ake JA; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Trautmann L; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Vasan S; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Robb ML; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Krebs SJ; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Paquin-Proulx D; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Rolland M; US Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA. Electronic address: mrolland@hivresearch.org.
Cell Rep ; 43(6): 114344, 2024 Jun 25.
Article em En | MEDLINE | ID: mdl-38850529
ABSTRACT
A heterologous Ad26/MVA vaccine was given prior to an analytic treatment interruption (ATI) in people living with HIV-1 (mainly CRF01_AE) who initiated antiretroviral treatment (ART) during acute HIV-1. We investigate the impact of Ad26/MVA vaccination on antibody (Ab)-mediated immune responses and their effect on time to viral rebound. The vaccine mainly triggers vaccine-matched binding Abs while, upon viral rebound post ATI, infection-specific CRF01_AE binding Abs increase in all participants. Binding Abs are not associated with time to viral rebound. The Ad26/MVA mosaic vaccine profile consists of correlated non-CRF01_AE binding Ab and Fc effector features, with strong Ab-dependent cellular phagocytosis (ADCP) responses. CRF01_AE-specific ADCP responses (measured either prior to or post ATI) are significantly higher in individuals with delayed viral rebound. Our results suggest that vaccines eliciting cross-reactive responses with circulating viruses in a target population could be beneficial and that ADCP responses may play a role in viral control post treatment interruption.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fagocitose / Infecções por HIV / HIV-1 / Vacinas contra a AIDS / Carga Viral Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fagocitose / Infecções por HIV / HIV-1 / Vacinas contra a AIDS / Carga Viral Idioma: En Ano de publicação: 2024 Tipo de documento: Article