Re-evaluating TRP channel mechanosensitivity.
Trends Biochem Sci
; 49(8): 693-702, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38851904
ABSTRACT
Transient receptor potential (TRP) channels are implicated in a wide array of mechanotransduction processes. However, a question remains whether TRP channels directly sense mechanical force, thus acting as primary mechanotransducers. We use several recent examples to demonstrate the difficulty in definitively ascribing mechanosensitivity to TRP channel subfamilies. Ultimately, despite being implicated in an ever-growing list of mechanosignalling events in most cases limited robust or reproducible evidence supports the contention that TRP channels act as primary transducers of mechanical forces. They either (i) possess unique and as yet unspecified structural or local requirements for mechanosensitivity; or (ii) act as mechanoamplifiers responding downstream of the activation of a primary mechanotransducer that could include Ca2+-permeable mechanosensitive (MS) channels or other potentially unidentified mechanosensors.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Mecanotransdução Celular
/
Canais de Potencial de Receptor Transitório
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article