Augustus Waller's foresight realized: SARM1 in peripheral neuropathies.
Curr Opin Neurobiol
; 87: 102884, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38852438
ABSTRACT
Peripheral neuropathy is a common neurodegenerative condition characterized by numbness, tingling, pain, and weakness that frequently starts in the distal limbs. Arising from multiple etiologies, many peripheral neuropathies exhibit a slowly progressive course due to axon degeneration for which no effective treatments exist. During the past decade, numerous crucial insights into mechanisms of axon degeneration in peripheral neuropathies emerged from experiments involving nerve-cutting procedures, revealing the central role of the SARM1 axon degeneration pathway in both. Here I review commonalities and differences in the role of SARM1 after nerve cut and in several acquired and inherited peripheral neuropathies. This new knowledge now paves the way for the development of therapeutics that directly address root causes of various kinds of neuropathies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças do Sistema Nervoso Periférico
/
Proteínas do Citoesqueleto
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Proteínas do Domínio Armadillo
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article