Pd-Catalyzed Hydroboration of Vinylarenes with B2pin2.
J Org Chem
; 89(12): 9056-9062, 2024 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-38857440
ABSTRACT
A palladium(II)-catalyzed Markovnikov hydroboration of aryl alkenes with readily available bis(pinacolato)diboron (B2pin2) is reported. The reaction proceeded with low catalyst loading (0.5 mol %) in the absence of N- or P-containing ligands, affording the products in up to 90% yield. Trifluoracetic acid serves as the hydrogen source, enabling the synthesis of benzylic boronic esters under mild ambient conditions.
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MEDLINE
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En
Ano de publicação:
2024
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Article