Hypersensitivity to CGRP as a predictive biomarker of migraine prevention with erenumab.
Cephalalgia
; 44(6): 3331024241258734, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38859744
ABSTRACT
BACKGROUND:
The present study aimed to investigate the predictive value of calcitonin gene-related peptide (CGRP)-induced migraine attacks for effectiveness to erenumab treatment in people with migraine.METHODS:
In total, 139 participants with migraine underwent a single experimental day involving a 20-min infusion with CGRP. Following this, the participants entered a 24-week treatment period with erenumab. The primary endpoints were the predictive value of CGRP-induced migraine attacks on the effectiveness of erenumab, defined as ≥50% reduction in monthly migraine days, or ≥ 50% reduction in either monthly migraine or monthly headache days of moderate to severe intensity.RESULTS:
Among participants with CGRP-induced migraine attacks, 60 of 99 (61%) achieved ≥50% reduction in monthly migraine days during weeks 13-24 with erenumab. Conversely, 13 of 25 (52%) where CGRP infusion did not induce a migraine achieved the same endpoint (p = 0.498). There were no significant differences between the ≥50% reduction in either monthly migraine or monthly headache days of moderate to severe intensity between CGRP-sensitive and non-sensitive participants (p = 0.625).CONCLUSIONS:
Our findings suggest that the CGRP-provocation model cannot be used to predict erenumab's effectiveness. It remains uncertain whether this finding extends to other monoclonal antibodies targeting the CGRP ligand or to gepants.Trial Registration The study was registered at ClinicalTrials.gov (NCT04592952).Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Peptídeo Relacionado com Gene de Calcitonina
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Anticorpos Monoclonais Humanizados
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Antagonistas do Receptor do Peptídeo Relacionado ao Gene de Calcitonina
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Transtornos de Enxaqueca
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article