Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34.
Oncoimmunology
; 13(1): 2364958, 2024.
Article
em En
| MEDLINE
| ID: mdl-38872753
ABSTRACT
We have recently demonstrated that inhibiting VPS34 enhances T-cell-recruiting chemokines through the activation of the cGAS/STING pathway using the STING agonist ADU-S100. Combining VPS34 inhibitors with ADU-S100 increased cytokine release and improved tumor control in mouse models, suggesting a potential synergy between VPS34 inhibition and therapies based on STING agonists.
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Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Classe III de Fosfatidilinositol 3-Quinases
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Proteínas de Membrana
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Neoplasias
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article