Diabetes distress and depression are independently associated with gastrointestinal symptoms in type 2 diabetes in Bangladesh.

Kamruzzaman, M; Horowitz, M; Polonsky, W H; Talley, N J; Borg, M A; Rayner, C K; Jones, K L; Marathe, C S

Kamruzzaman, M; Horowitz, M; Polonsky, W H; Talley, N J; Borg, M A; Rayner, C K; Jones, K L; Marathe, C S.

Afiliação

Kamruzzaman M; Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
Horowitz M; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia.
Polonsky WH; Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh.
Talley NJ; Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
Borg MA; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia.
Rayner CK; Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Jones KL; Behavioral Diabetes Institute, San Diego, California, USA.
Marathe CS; University of California, San Diego, California, USA.

Diabet Med ; : e15379, 2024 Jun 17.

Article em En | MEDLINE | ID: mdl-38881382

ABSTRACT

ABSTRACT

BACKGROUND AND

AIMS:

Gastrointestinal (GI) symptoms, common in type 2 diabetes (T2D), are typically bothersome, socially embarrassing, and impact negatively on quality of life. They may also contribute to diabetes distress (DD), but this has never been formally evaluated. We aimed to investigate the relationships between GI symptoms, DD and depressive symptoms in a large cohort of individuals with T2D in Bangladesh. MATERIALS AND

METHODS:

1406 unselected T2D individuals (female 58.8%; mean age 51.0 ± 12.5 years) from four diabetes clinics in Bangladesh completed validated questionnaires evaluating GI symptoms (PAGI-SYM), DD (DDS-17) and depressive symptoms (PHQ-9).

RESULTS:

31.1% of participants reported GI symptoms (36.2% females, 23.7% males), while 51.1% had elevated DD and 37.8% depressive symptoms. GI symptoms exhibited independent relationships with both DD and depressive symptoms, and their likelihood was higher among those with DD (OR 3.6 [2.2-5.6] and with depressive symptoms (OR 5.9 [3.5-9.9]).