A novel NIR-II albumin-escaping probe for cerebral arteries and perfusion imaging in stroke mice model.
Biomaterials
; 311: 122664, 2024 Dec.
Article
em En
| MEDLINE
| ID: mdl-38889597
ABSTRACT
In order to guide the formulation of post-stroke treatment strategy in time, it is necessary to have real-time feedback on collateral circulation and revascularization. Currently used near-infrared II (NIR-II) probes have inherent binding with endogenous albumin, resulting in significant background signals and uncontrollable pharmacokinetics. Therefore, the albumin-escaping properties of the new probe, IR-808AC, was designed, which achieved timely excretion and low background signal, enabling the short-term repeatable injection for visualization of cerebral vessels and perfusion. We further achieved continuous observation of changes in collateral vessels and perfusion during the 7-d period in middle cerebral artery occlusion mice using IR-808AC in vivo. Furthermore, using IR-808AC, we confirmed that remote ischemic conditioning could promote collateral vessels and perfusion. Finally, we evaluated the revascularization after thrombolysis on time in embolic stroke mice using IR-808AC. Overall, our study introduces a novel methodology for safe, non-invasive, and repeatable assessment of collateral circulation and revascularization in real-time that is crucial for the optimization of treatment strategies.
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Base de dados:
MEDLINE
Assunto principal:
Acidente Vascular Cerebral
/
Modelos Animais de Doenças
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article