Senescence and tissue fibrosis: opportunities for therapeutic targeting.
Trends Mol Med
; 2024 Jun 17.
Article
em En
| MEDLINE
| ID: mdl-38890028
ABSTRACT
Cellular senescence is a key hallmark of aging. It has now emerged as a key mediator in normal tissue turnover and is associated with a variety of age-related diseases, including organ-specific fibrosis and systemic sclerosis (SSc). This review discusses the recent evidence of the role of senescence in tissue fibrosis, with an emphasis on SSc, a systemic autoimmune rheumatic disease. We discuss the physiological role of these cells, their role in fibrosis, and that targeting these cells specifically could be a new therapeutic avenue in fibrotic disease. We argue that targeting senescent cells, with senolytics or senomorphs, is a viable therapeutic target in fibrotic diseases which remain largely intractable.
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MEDLINE
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En
Ano de publicação:
2024
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Article