1,3,5-Triazine as Branching Connector for the Construction of Novel Antimicrobial Peptide Dendrimers: Synthesis and Biological Characterization.
Int J Mol Sci
; 25(11)2024 May 28.
Article
em En
| MEDLINE
| ID: mdl-38892071
ABSTRACT
Peptides displaying antimicrobial properties are being regarded as useful tools to evade and combat antimicrobial resistance, a major public health challenge. Here we have addressed dendrimers, attractive molecules in pharmaceutical innovation and development displaying broad biological activity. Triazine-based dendrimers were fully synthesized in the solid phase, and their antimicrobial activity and some insights into their mechanisms of action were explored. Triazine is present in a large number of compounds with highly diverse biological targets with broad biological activities and could be an excellent branching unit to accommodate peptides. Our results show that the novel peptide dendrimers synthesized have remarkable antimicrobial activity against Gram-negative bacteria (E. coli and P. aeruginosa) and suggest that they may be useful in neutralizing the effect of efflux machinery on resistance.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triazinas
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Testes de Sensibilidade Microbiana
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Escherichia coli
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Dendrímeros
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article