Systematic review and evidence gap assessment of the clinical, quality of life, and economic burden of alpha-thalassemia.
EJHaem
; 5(3): 541-547, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38895066
ABSTRACT
A recent evidence gaps assessment of the clinical, health-related quality of life, and economic burden associated with α-thalassemia is lacking. We conducted a systematic literature review (SLR) following the methodological and reporting requirements of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the Cochrane Handbook for Systematic Reviews, using available literature over the past decade. This SLR identified a considerable evidence gap with regard to understanding the current burden of α-thalassemia as evident from paucity of studies published in the past 10 years. The limited data available still indicate that patients with α-thalassemia experience substantial morbidity and quality of life/economic burden that is generally comparable to patients with ß-thalassemia.
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MEDLINE
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En
Ano de publicação:
2024
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Article