Oropharyngeal Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN): A Case Report and Literature Review.
Head Neck Pathol
; 18(1): 53, 2024 Jun 19.
Article
em En
| MEDLINE
| ID: mdl-38896312
ABSTRACT
Mixed neuroendocrine-nonneuroendocrine (MiNEN) neoplasms in the head and neck are exceptionally rare biphasic tumors with unclear pathogenesis and an aggressive clinical behavior. This is the first reported case of an oropharyngeal MiNEN with the nonneuroendocrine component being an HPV-associated adenocarcinoma. The tumor arose in a 56 year-old male with history of long-term cigarette smoking and was composed of an adenocarcinoma intermixed with a small cell neuroendocrine carcinoma. P16 immunohistochemical stain and HPV16/18 in-situ hybridization were strongly and diffusely expressed in both components.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Orofaríngeas
/
Carcinoma Neuroendócrino
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article