Comparison of outcomes of abdominoperineal resection vs low anterior resection in very-low rectal cancer.
J Gastrointest Surg
; 2024 Jun 17.
Article
em En
| MEDLINE
| ID: mdl-38897287
ABSTRACT
BACKGROUND:
The management of very-low rectal cancer is one of the most challenging issues faced by general and colorectal surgeons. Many feel compelled to pursue abdominoperineal resection (APR) over low anterior resection (LAR) to optimize oncologic outcomes. This study aimed to determine differences in long-term oncologic outcomes between patients undergoing APR or LAR for very-low rectal cancer.METHODS:
The United States Rectal Cancer Consortium (2010-2016) was queried for adults who underwent either APR or LAR for stage I-III rectal cancers < 5 cm from anorectal junction and met inclusion criteria. The primary outcome was disease-free survival. Secondary outcomes included overall survival, length of stay, complications, recurrence location, and perioperative factors.RESULTS:
A total of 431 patients with very-low rectal cancer who underwent APR or LAR were identified; 154 (35.7%) underwent APR. The overall recurrence rate was 19.6%. The median follow-up was 42.5 months. An analysis adjusted for demographics and pathologic stage observed no difference in disease-free survival between operative types (APR-hazard ratio [HR] = 0.90, 95% CI 0.53-1.52, P = .70). Secondary outcomes demonstrated no significant difference between operation types, including overall survival (HR = 1.29, 95% CI 0.71-2.32, P = .39), complications (OR = 1.53, 95% CI 0.94-2.50, P = .12), or length of stay (estimate 0.04, SE = 0.25, P = .54).CONCLUSION:
We observed no significant difference in disease-free survival or overall survival between patients undergoing APR or LAR for very-low rectal cancer. This analysis supports the treatment of very-low rectal cancer, without sphincter involvement, by either APR or LAR.
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MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article