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The effect of silver diammine fluoride on In Vitro Enamel caries lesion remineralization and staining as a function of lesion baseline mineral distribution.
AlMady, Fahad; Abogazalah, Naif; Dehalian, Laila Al; Capin, Oriana; Hara, Anderson T; Eckert, George J; Lippert, Frank.
Afiliação
  • AlMady F; Department of Cariology and Operative Dentistry, Indiana University School of Dentistry, Indianapolis, IN, USA; King Faisal University, Restorative Department, School of Dentistry AlAhsa, Saudi Arabia.
  • Abogazalah N; Department of Cariology and Operative Dentistry, Indiana University School of Dentistry, Indianapolis, IN, USA; Department of Restorative Dental Sciences, King Khalid University College of Dentistry, Abha, Saudi Arabia.
  • Dehalian LA; Department of restorative dental sciences, college of dentistry, Imam Abdulrahman bin Faisal university, Dammam, Saudi Arabia.
  • Capin O; Department of Cariology and Operative Dentistry, Indiana University School of Dentistry, Indianapolis, IN, USA.
  • Hara AT; Department of Cariology and Operative Dentistry, Indiana University School of Dentistry, Indianapolis, IN, USA.
  • Eckert GJ; Department of Biostatistics and Health Data Science. Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Lippert F; Department of Cariology and Operative Dentistry, Indiana University School of Dentistry, Indianapolis, IN, USA. Electronic address: flippert@iu.edu.
J Dent ; 147: 105139, 2024 08.
Article em En | MEDLINE | ID: mdl-38897540
ABSTRACT

OBJECTIVES:

to investigate whether baseline mineral distribution modulates the ability of silver diammine fluoride (SDF) to remineralize and stain enamel caries lesions.

METHODS:

This laboratory study followed a 3 [treatment SDF/fluoride varnish (FV)/deionized water (DIW)] ×3 [lesion protocol methylcellulose (MeC)/hydroxyethylcellulose (HEC)/Carbopol 907 (C907)] factorial design. Lesions were created in bovine enamel specimens (n = 20). Treatments were applied and lesions remineralized in artificial saliva. Digital transverse microradiography (TMR-D) was used to analyze lesions. Lesion color was monitored spectrophotometrically. The effects of lesion protocol and treatment on changes in lesion depth (ΔLD), mineral loss (ΔΔZ), maximum mineral density at the surface zone (ΔSZmax), and color changes related to remineralization (ΔL*remin) were analyzed using two-way ANOVA.

RESULTS:

The treatment×lesion protocol interaction was significant for ΔΔZ (p < 0.01) and ΔL*remin (p < 0.01), however not for ΔLD (p = 0.23) or ΔSZmax (p = 0.91). There were no differences in ΔΔZ between treatments in HEC and C907 lesions. However, DIW resulted in more remineralization than both SDF (p < 0.01) and FV (p = 0.01) in MeC lesions. Considering changes from lesion baseline after remineralization in MeC lesions, SDF treatment resulted in the highest mineral gain in the surface zone. However, DIW revealed the highest mineral gain after remineralization in the lesion body. SDF stained lesions with the intensity increasing after remineralization in C907 lesions, whereas staining decreased in MeC and HEC lesions.

CONCLUSION:

High fluoride treatments can interfere with continuous remineralization of caries lesions due to partial arrest. Baseline lesion mineral distribution affects SDF's ability to enhance remineralization and the staining caused by SDF. CLINICAL

SIGNIFICANCE:

SDF is being used to arrest active caries lesions extending into dentin and to treat dentin hypersensitivity. This study shed light on SDF's effect on an isolated process in dental caries only, remineralization. It achieved this by examining enamel caries lesions with differing mineral distributions and assessing their staining properties.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Remineralização Dentária / Microrradiografia / Cariostáticos / Fluoretos Tópicos / Compostos de Prata / Cárie Dentária / Esmalte Dentário / Compostos de Amônio Quaternário Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Remineralização Dentária / Microrradiografia / Cariostáticos / Fluoretos Tópicos / Compostos de Prata / Cárie Dentária / Esmalte Dentário / Compostos de Amônio Quaternário Idioma: En Ano de publicação: 2024 Tipo de documento: Article