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Intestinal linoleic acid contributes to the protective effects of Akkermansia muciniphila against Listeria monocytogenes infection in mice.
Jin, Tong; Zhang, Yingying; Yang, Yanpeng; Teng, Yue; Yan, Chunhong; Shan, Zhongguo; Meng, Jianghong; Xia, Xiaodong.
Afiliação
  • Jin T; State Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology Dalian Polytechnic University Dalian China.
  • Zhang Y; Department of Food Safety, College of Food Science and Engineering Northwest A&F University Xianyang China.
  • Yang Y; Department of Food Safety, College of Food Science and Engineering Northwest A&F University Xianyang China.
  • Teng Y; Department of Food Safety, College of Food Science and Engineering Northwest A&F University Xianyang China.
  • Yan C; State Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology Dalian Polytechnic University Dalian China.
  • Shan Z; State Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology Dalian Polytechnic University Dalian China.
  • Meng J; Department of Food Safety, College of Food Science and Engineering Northwest A&F University Xianyang China.
  • Xia X; Department of Food Science and Nutrition University of Maryland College Park Maryland USA.
Imeta ; 3(3): e196, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38898984
ABSTRACT
Akkermansia muciniphila pretreatment mitigated Listeria monocytogenes infection in mice. A. muciniphila improved gut microbiota disturbed by L. monocytogenes infection and significantly increased the level of intestinal linoleic acid in mice. Linoleic acid strengthened the intestinal epithelial barrier and reduced pathogen translocation partly by regulating NF-κB/MLCK pathway in a GPR40-dependent manner.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article