Direct GPCR-EGFR interaction enables synergistic membrane-to-nucleus information transfer.

Gekle, Michael; Eckenstaler, Robert; Braun, Heike; Olgac, Abdurrahman; Robaa, Dina; Mildenberger, Sigrid; Dubourg, Virginie; Schreier, Barbara; Sippl, Wolfgang; Benndorf, Ralf

Gekle, Michael; Eckenstaler, Robert; Braun, Heike; Olgac, Abdurrahman; Robaa, Dina; Mildenberger, Sigrid; Dubourg, Virginie; Schreier, Barbara; Sippl, Wolfgang; Benndorf, Ralf.

Afiliação

Gekle M; Julius-Bernstein-Institute of Physiology, Martin Luther University Halle-Wittenberg, 06112, Halle (Saale), Germany. michael.gekle@medizin-halle.de.
Eckenstaler R; Institute of Pharmacy, Department of Clinical Pharmacy and Pharmacotherapy, Martin Luther University Halle-Wittenberg, Halle, Germany.
Braun H; Institute of Pharmacy, Department of Clinical Pharmacy and Pharmacotherapy, Martin Luther University Halle-Wittenberg, Halle, Germany.
Olgac A; Institute of Pharmacy, Department of Medical Chemistry, Martin Luther University Halle-Wittenberg, Halle, Germany.
Robaa D; Institute of Pharmacy, Department of Medical Chemistry, Martin Luther University Halle-Wittenberg, Halle, Germany.
Mildenberger S; Julius-Bernstein-Institute of Physiology, Martin Luther University Halle-Wittenberg, 06112, Halle (Saale), Germany.
Dubourg V; Julius-Bernstein-Institute of Physiology, Martin Luther University Halle-Wittenberg, 06112, Halle (Saale), Germany.
Schreier B; Julius-Bernstein-Institute of Physiology, Martin Luther University Halle-Wittenberg, 06112, Halle (Saale), Germany.
Sippl W; Institute of Pharmacy, Department of Medical Chemistry, Martin Luther University Halle-Wittenberg, Halle, Germany.
Benndorf R; Institute of Pharmacy, Department of Clinical Pharmacy and Pharmacotherapy, Martin Luther University Halle-Wittenberg, Halle, Germany.

Cell Mol Life Sci ; 81(1): 272, 2024 Jun 20.

Article em En | MEDLINE | ID: mdl-38900158

Assuntos

Núcleo Celular; Receptores ErbB; Receptor Tipo 1 de Angiotensina; Receptores ErbB/metabolismo; Humanos; Receptor Tipo 1 de Angiotensina/metabolismo; Receptor Tipo 1 de Angiotensina/genética; Núcleo Celular/metabolismo; Transferência Ressonante de Energia de Fluorescência; Fosforilação; Receptores Acoplados a Proteínas G/metabolismo; Receptores Acoplados a Proteínas G/genética; Membrana Celular/metabolismo; Angiotensina II/metabolismo; Angiotensina II/farmacologia; Fator de Crescimento Epidérmico/metabolismo; Células HEK293; Ligação Proteica; Fator de Resposta Sérica/metabolismo; Fator de Resposta Sérica/genética

Palavras-chave

AT1R; Angiotensin II receptor type 1; EGFR; Epidermal growth factor receptor; Heteromerizsation; Serum response factor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Núcleo Celular / Receptor Tipo 1 de Angiotensina / Receptores ErbB Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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