Understanding the influence of cytokines in intrauterine hepatitis B transmission: A cross-sectional study in China.
Cytokine
; 181: 156670, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38901264
ABSTRACT
Cytokines may related to intrauterine Hepatitis B virus (HBV) transmission. 205 HBsAg(+) pregnant cases and 74 HBsAg(-) women were included. Neonatal blood samples were taken within 24 h of delivery and before HBV vaccinations. Serological HBV biomarkers and cytokines were detected. 21.9 % of the newborns from HBsAg(+) women were intrauterinally transmitted, including 7.3 % with dominant transmission (DBT) and 14.6 % occult transmission (OBT). HBV DNA load (odd ratio [OR], 1.44; 95 % confidence interval [CI], 1.05-1.98), interferon-γ (IFN-γ) (OR, 1.01; 95 %CI, 1.00-1.02) and toll-like receptor 9 (TLR9) (OR, 1.27; 95 %CI, 1.06-1.52) positively correlated with DBT. Only IFN-γ (OR, 1.01; 95 %CI, 1.00-1.01) positively associated with OBT. According to the generated restricted cubic spline, TLR9 was positively correlates with rise of DBT in a log-shape. It may be possible to develop a nomogram which intercalates these factors to predict intrauterine HBV transmissions. Further research should consider immune processes involved in chorioamnionitis.
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Base de dados:
MEDLINE
Assunto principal:
Vírus da Hepatite B
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Citocinas
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Transmissão Vertical de Doenças Infecciosas
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Receptor Toll-Like 9
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Hepatite B
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article