Molecular insights to therapeutic in cancer: role of exosomes in tumor microenvironment, metastatic progression and drug resistance.
Drug Discov Today
; 29(8): 104061, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38901672
ABSTRACT
Exosomes play a pivotal part in cancer progression and metastasis by transferring various biomolecules. Recent research highlights their involvement in tumor microenvironment remodeling, mediating metastasis, tumor heterogeneity and drug resistance. The unique cargo carried by exosomes garners the interest of researchers owing to its potential as a stage-specific biomarker for early cancer detection and its role in monitoring personalized treatment. However, unanswered questions hinder a comprehensive understanding of exosomes and their cargo in this context. This review discusses recent advancements and proposes novel ideas for exploring exosomes in cancer progression, aiming to deepen our understanding and improve treatment approaches.
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Base de dados:
MEDLINE
Assunto principal:
Progressão da Doença
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Resistencia a Medicamentos Antineoplásicos
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Exossomos
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Microambiente Tumoral
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Metástase Neoplásica
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Neoplasias
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article