Wide distribution of plasmid mediated quinolone resistance gene, qnrS, among Salmonella spp. isolated from canal water in Thailand.
J Appl Microbiol
; 135(6)2024 Jun 03.
Article
em En
| MEDLINE
| ID: mdl-38908908
ABSTRACT
AIMS:
This research focused on assessing the prevalence of plasmid-mediated quinolone resistance (PMQR) determinants and antimicrobial susceptibility in Salmonella strains isolated from Thai canal water. METHODS ANDRESULTS:
From 2016 to 2020, 333 water samples were collected from six canals across Bangkok, Thailand. Salmonella spp. was isolated, PMQR genes were detected through polymerase chain reactions, and the antimicrobial susceptibility was examined using the disk diffusion method. The results indicated a 92.2% prevalence of Salmonella spp. in canal water, being serogroups B and C the most frequently detected. Overall, 35.3% of isolates harbored PMQR genes, being qnrS the most prevalent gene (97.2%, n = 137/141). Other PMQR genes, including qnrB, qnrD, oqxAB, and aac(6')-Ib-cr, were detected. Notably, six isolates harbored multiple PMQR genes. Furthermore, 9.3% and 3.8% of the overall isolates were resistant to nalidixic acid (NAL) and ciprofloxacin (CIP), respectively. PMQR-positive isolates showed higher rates of non-susceptibility to both NAL (48.2%, n = 68/141) and CIP (92.2%, n = 130/141) compared to PMQR-negative isolates (NAL 8.9%, n = 23/258; CIP 11.2%, n = 30/258).CONCLUSIONS:
The high prevalence of Salmonella spp., significant PMQR-positive, and reduced susceptibility isolates in canal water is of public health concern in Bangkok.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Plasmídeos
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Salmonella
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Microbiologia da Água
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Testes de Sensibilidade Microbiana
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Quinolonas
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Farmacorresistência Bacteriana
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Antibacterianos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article