GHS-R1a deficiency protects against lipopolysaccharide-induced spatial memory impairment in mice.
Biochem Biophys Res Commun
; 727: 150270, 2024 10 01.
Article
em En
| MEDLINE
| ID: mdl-38917617
ABSTRACT
Neuroinflammation has been implicated in cognitive deficits of neurological and neurodegenerative diseases. There is abundant evidence that the application of ghrelin, an orexigenic hormone regulating appetite and energy balance, abrogates neuroinflammation and rescues associated memory impairment. However, the underlying mechanism is uncertain. In this study, we find that both intraperitoneal (i.p.) and intracerebroventricular (i.c.v.) administration of lipopolysaccharide (LPS) impairs spatial memory in mice. LPS treatment causes neuroinflammation and microglial activation in the hippocampus. Ghsr1a deletion suppresses LPS-induced microglial activation and neuroinflammation, and rescued LPS-induced memory impairment. Our findings thus suggest that GHS-R1a signaling may promote microglial immunoactivation and contribute to LPS-induced neuroinflammation. GHS-R1a may be a new therapeutic target for cognitive dysfunction associated with inflammatory conditions.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Lipopolissacarídeos
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Microglia
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Receptores de Grelina
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Memória Espacial
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Transtornos da Memória
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Camundongos Endogâmicos C57BL
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article