Registries or non-pharmacological observational studies? An operational attempt to draw the line and to provide some suggestions for the ethical evaluation of rare disease registries.
Ann Ist Super Sanita
; 60(1): 29-36, 2024.
Article
em En
| MEDLINE
| ID: mdl-38920256
ABSTRACT
Originally established to evaluate the ethical aspects of clinical trials, Ethics Committees (ECs) are now requested to review different types of projects, including, among others, observational studies and disease registries. In Italy, clinical trials on medicinal products for human use and on medical devices are regulated by EU Regulation 536/2014, EU Regulation 2017/745, and 2017/746 while pharmacological observational studies are regulated by the Italian Medicines Agency guidelines of 2008 and by Ministerial Decree of November 30th, 2021. The other types of studies are not strictly regulated, causing discrepancies in their definition and assessment by the ECs, and slowdowns in the start of projects. The present contribution aims to propose definitions and distinctions between non-pharmacological observational studies and disease registries, which constitute different entities but are often assimilated by ECs, and to formulate suggestions for the evaluation of rare disease registries, which are an expanding research area of interest.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistema de Registros
/
Doenças Raras
/
Estudos Observacionais como Assunto
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article