The Long-Term Effect of Weight Loss on the Prevention of Progression to Cirrhosis among Patients with Obesity and MASH-Related F3 Liver Fibrosis.
Int J Environ Res Public Health
; 21(6)2024 May 30.
Article
em En
| MEDLINE
| ID: mdl-38928954
ABSTRACT
This multi-center retrospective study examined the effect of weight loss on the prevention of progression to cirrhosis in a sample exclusively composed of patients with obesity and MASH-related F3 liver fibrosis. Adult patients with obesity and biopsy-confirmed MASH-related F3 liver fibrosis (n = 101) from two liver transplant centers in the US were included in the study. A higher proportion of patients who did not progress to cirrhosis achieved >5% weight loss at follow-up (59% vs. 30%, p = 0.045). In multivariable analysis, patients with >5% weight loss at follow-up had a lower hazard of developing cirrhosis compared to patients with no weight loss or weight gain (HR 0.29, 95%, CI 0.08-0.96); whereas, diabetes (HR 3.24, 95%, CI 1.21-8.67) and higher LDL levels (HR 1.02, 95%, CI 1.01-1.04) were associated with higher hazards of progression to cirrhosis. Weight loss >5% has the potential to prevent disease progression to cirrhosis in patients with obesity and MASH-related F3 liver fibrosis. The realization of this benefit requires weight loss maintenance longer than one year. Larger prospective studies are needed to determine how weight loss impacts other patient-centered outcomes such as mortality, hepatic decompensation, and hepatocellular carcinoma in patients with obesity and MASH-related F3 liver fibrosis.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Redução de Peso
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Progressão da Doença
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Cirrose Hepática
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Obesidade
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article