Update on Early-Life T Cells: Impact on Oral Rotavirus Vaccines.
Viruses
; 16(6)2024 May 22.
Article
em En
| MEDLINE
| ID: mdl-38932111
ABSTRACT
Rotavirus infection continues to be a significant public health problem in developing countries, despite the availability of several vaccines. The efficacy of oral rotavirus vaccines in young children may be affected by significant immunological differences between individuals in early life and adults. Therefore, understanding the dynamics of early-life systemic and mucosal immune responses and the factors that affect them is essential to improve the current rotavirus vaccines and develop the next generation of mucosal vaccines. This review focuses on the advances in T-cell development during early life in mice and humans, discussing how immune homeostasis and response to pathogens is established in this period compared to adults. Finally, the review explores how this knowledge of early-life T-cell immunity could be utilized to enhance current and novel rotavirus vaccines.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por Rotavirus
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Linfócitos T
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Rotavirus
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Vacinas contra Rotavirus
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article