Parkinson's Disease and Mitotherapy-Based Approaches towards α-Synucleinopathies.
J Integr Neurosci
; 23(6): 109, 2024 May 29.
Article
em En
| MEDLINE
| ID: mdl-38940084
ABSTRACT
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain and the formation of intracellular protein aggregates known as Lewy bodies, of which a major component is the protein α-synuclein. Several studies have suggested that mitochondria play a central role in the pathogenesis of PD, encompassing both familial and sporadic forms of the disease. Mitochondrial dysfunction is attributed to bioenergetic impairment, increased oxidative stress, damage to mitochondrial DNA, and alteration in mitochondrial morphology. These alterations may contribute to improper functioning of the central nervous system and ultimately lead to neurodegeneration. The perturbation of mitochondrial function makes it a potential target, worthy of exploration for neuroprotective therapies and to improve mitochondrial health in PD. Thus, in the current review, we provide an update on mitochondria-based therapeutic approaches toward α-synucleinopathies in PD.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Sinucleinopatias
/
Mitocôndrias
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article