miR-142-3p alleviates neuronal apoptosis in Parkinson's disease via negatively regulating C9orf72.
Neurosci Lett
; 836: 137887, 2024 Jul 27.
Article
em En
| MEDLINE
| ID: mdl-38942112
ABSTRACT
Although microRNA (miRNA) have important clinical prospects in the early diagnosis and treatment of PD, the functions and mechanisms of miRNAs in PD models remain poorly defined. In this study, we screened 9 miRNAs that differently expressed in PD patients and found that miR-142-3p expression was downregulated in both animal and cell models of PD. We showed that overexpression of miR-142-3p significantly alleviates the neuronal damage induced by MPP+, while knockdown of miR-142-3p exacerbates the neuronal damage caused by MPP+. We further found that miR-142-3p targets and inhibits the expression of C9orf72. Knockdown of C9orf72 mitigated neuronal autophagy dysfunction by reducing excessive activation of the AKT/mTOR pathway after MPP+ stimulation, thereby exerted neuroprotective effects. This study reveals that miR-142-3p protects neuron in PD pathogenesis via negatively regulating C9orf72 and enhancing autophagy. Our findings provides an insight into the development of potential biomarkers and therapeutic targets for PD.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
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Autofagia
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Apoptose
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MicroRNAs
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Proteína C9orf72
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Neurônios
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article