Senescent cell-derived vaccines: a new concept towards an immune response against cancer and aging?
Aging (Albany NY)
; 16(12): 10657-10665, 2024 06 26.
Article
em En
| MEDLINE
| ID: mdl-38942604
ABSTRACT
Two recent seminal works have untangled the intricate role of tumor-associated senescent cells in cancer progression, or regression, by guiding our immune system against cancer cells. The characterization of these unique, yet diverse cell populations, should be considered, particularly when contemplating the use of senolytics, which are drugs that selectively eliminate senescent cells, in a cancer framework. Here, we will describe the current knowledge in this field. In particular, we will discuss how the presence of senescent cells in tumors could be used as a therapeutic target in immunogenic cancers and how we may hypothetically design an adaptive anti-aging vaccine.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
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Senescência Celular
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Vacinas Anticâncer
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Neoplasias
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article