Higher Cerebrospinal Fluid Levels of Amyloid-ß40 Following Traumatic Brain Injury Relate to Confrontation Naming Performance.
J Alzheimers Dis
; 100(2): 539-550, 2024.
Article
em En
| MEDLINE
| ID: mdl-38943392
ABSTRACT
Background:
Traumatic brain injury (TBI) may confer risk for Alzheimer's disease (AD) through amyloid-ß (Aß) overproduction. However, the relationship between TBI and Aß levels in cerebrospinal fluid (CSF) remains unclear.Objective:
To explore whether Aß overproduction is implicated in the relationship between TBI and AD, we compared CSF levels of Aß in individuals with a TBI history versus controls (CTRLs) and related CSF Aß levels to cognitive markers associated with preclinical AD.Methods:
Participants were 112 non-impaired Veterans (TBIâ=â56, CTRLâ=â56) from the Alzheimer's Disease Neuroimaging Initiative-Department of Defense database with available cognitive data (Boston Naming Test [BNT], Rey Auditory Verbal Learning Test [AVLT]) and CSF measures of Aß42, Aß40, and Aß38. Mediation models explored relationships between TBI history and BNT scores with Aß peptides as mediators.Results:
The TBI group had higher CSF Aß40 (tâ=â-2.43, pâ=â0.017) and Aß38 (tâ=â-2.10, pâ=â0.038) levels than the CTRL group, but groups did not differ in CSF Aß42 levels or Aß42/Aß40 ratios (pâ>â0.05). Both Aß peptides negatively correlated with BNT (Aß40 rhoâ=â-0.20, pâ=â0.032; Aß38 rhoâ=â-0.19, pâ=â0.048) but not AVLT (pâ>â0.05). Aß40 had a significant indirect effect on the relationship between TBI and BNT performance (ß=â-0.16, 95% CI [-0.393, -0.004], PMâ=â0.54).Conclusions:
TBI may increase AD risk and cognitive vulnerability through Aß overproduction. Biomarker models incorporating multiple Aß peptides may help identify AD risk among those with TBI.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Peptídeos beta-Amiloides
/
Lesões Encefálicas Traumáticas
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article